Effect of my-leran and 6-mercaptopurine (6-MP) on the serum level of vitamin B12 in chronic myelocytic leukemia.

Effect of Myleran and 6-Mercaptopurine (6.MP) on the Serum Level of Vitamin B,,, in Chronic Myelocytic Leukemia

In the present study, serum vitamin B,2 determinations and various clinical and hematologic measurements were made on patients with chronic myelocytic leukemia before and during 6-MP or Myleran therapy and also at regular intervals during the first remission period. The results indicate that a reduction in total leukocytes following therapy is followed by a gradual lowering of serum vitamin B12...

NUDT15 genetic variants and 6-mercaptopurine intolerance in pediatric acute lymphoblastic leukemia: an updated review

Acute lymphoblastic leukemia (ALL) accounts for nearly 30% of pediatric cancers. The maintenance treatment for ALL comprises daily oral 6-mercaptopurine (6-MP) and weekly methotrexate (MTX). 6-MP is a purine analog that can significantly improve the long-term survival of ALL patients. Despite more than 90% of 5-year survival of childhood ALL in developed countries, treatment interruption due to...

مقایسه سطح سرمی هموسیستیین در بیماران مبتلا به دیابت نوع 2 مصرف‌کننده متفورمین و گلی‌بن‌کلامید

Background: Diabetes mellitus is the most common cause of renal failure, blindness, non- traumatic amputation and neuropathy. Homocysteine, a sulfurated amino acid, has a close correlation with Methionine and Cysteine. The conversion of Methionine to Homocysteine and Cysteine is required coenzymes like vitamin B6, B12 and Folate. The effect of Metformin on serum Homocysteine level by decreasing...

The effect of oral calcium on serum level of vitamin B12 in patients with type 2 diabetes

The relationship between serum vitamin D and vitamin B12 levels and diabetic peripheral neuropathy

Abstract Objective: Diabetic peripheral neuropathy (DPN) is one of the most common complications of diabetes. Beside the known factors such as hyperglycemia in the pathogenesis of this complication, other etiologies may play role in the pathogenesis of this complication. The aim of this study was the evaluation of the role of serum vitamin D and vitamin B12 levels in this process. Material a...